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Monday, July 21, 2025

J.P. Morgan quant's 20 highest beta stocks in the S&P 500

Beta measures stock price volatility and a high-beta stock (with a beta above 1.0) tends to more risky with greater potential reward. Investors are now flocking to high-beta names after previously crowding into momentum stocks (due to megacap and AI fear of missing out) in January and low volatility in April (on worries about tariffs, a recession and AI overspending).
 
  1. Super Micro Computer (SMCI), beta score 3.37
  2. Coinbase Global (COIN), 2.82
  3. Palantir Technologies (PLTR), 2.41
  4. Monolithic Power Systems (MPWR), 2.39
  5. Broadcom (AVGO), 2.35
  6. Nvidia (NVDA), 2.32
  7. Micron Technology (MU), 2.30
  8. Western Digital (WDC), 2.19
  9. Arista Networks (ANET), 2.17
  10. AMD (AMD), 2.13
  11. Dell (DELL), 2.08
  12. Vistra (VST), 2.00
  13. Lam Research (LRCX), 1.98
  14. Microchip Technology (MCHP), 1.92
  15. Crowdstrike (CRWD), 1.91
  16. KKR (KKR), 1.90
  17. Teradyne (TER), 1.88
  18. KLA (KLAC), 1.87
  19. Carnival (CCL), 1.87
  20. Tesla (TSLA), 1.86


AVGO - Broadcom Inc - Stock Price Chart CCL - Carnival Corp - Stock Price Chart COIN - Coinbase Global Inc - Stock Price Chart LRCX - Lam Research Corp - Stock Price Chart ANET - Arista Networks Inc - Stock Price Chart MCHP - Microchip Technology, Inc - Stock Price Chart

DELL - Dell Technologies Inc - Stock Price Chart VST - Vistra Corp - Stock Price Chart WDC - Western Digital Corp - Stock Price Chart CRWD - Crowdstrike Holdings Inc - Stock Price Chart KKR - KKR & Co. Inc - Stock Price Chart TER - Teradyne, Inc - Stock Price Chart

KLAC - KLA Corp - Stock Price Chart MPWR - Monolithic Power System Inc - Stock Price Chart
                   


Earnings this week : Jul 21 - 25 , 25 (wk 30)

Monday (July 21)
  • Morning: CLF DPZ ROP VZ
  • Afternoon: AGYS ARE BOKF CALX CCK ELS MEDP NXPI RLI STLD WRB WTFC ZION
Tuesday (July 22)
  • Morning: AVY BMI CBU DGX DHI DHR EFX FBP GM GPC HAL HOPE IPG IQV IVZ KEY KO LMT MSCI NOC ONB PCAR PHM PM PNR RTX SHW SYF THC VMI
  • Afternoon: BKR CALM CATY CB COF CSGP ENPH EQT EWBC ISRG MANH MTDR NBHC PEGA PFSI RNST RRC SAP TRMK TXN VICR WFRD
Wednesday (July 23)
  • Morning: APH BKU BPOP BSX CME COOP FCX FI FRME GD GEV HAS HCSG HLT LII LW MCO MHO NEE NTRS NVR OTIS PB PRG PTEN T TDY TEL TMHC TNL UCB
  • Afternoon: ALK ASGN BANC CADE CCI CCS CHDN CLB CMG CSX CYH EGP EPRT FAF GGG GL GOOG GSHD IBM ICLR KALU KNX LUV LVS MAT MOH MTH MXL NOW OII ORLY PKG PLXS QS RBBN RHI RJF RNR ROL RS SEIC SIGI SON SSNC STC TMUS TSLA URI VKTX WEX WH
Thursday (July 24) 
  • Morning: AAL AB ADT ALLE AMBP AMP AOS AUB BC BFH BHLB BX CNP CNX CVBF DAR DOV DOW FCFS FCN FLEX FTI GPI HNI HON IMAX IRDM ITGR KDP LADR LAZ LECO LH LHX LKQ MBLY MHK NDAQ NOK NVCR ORI PFS PHIN POOL R RES RPM SAH STM THRM TPH TRU TSCO TXT UNP VC VLO VLY WAB WNS WST
  • Afternoon: ASB BYD COLB COUR CUBI DECK DLR DOC ENVA EW FFBC GBCI GLPI HXL INTC KN KNSL LBRT MC MGRC MTX NEM PECO SBCF SKYW SLM SSB VRSN WSFS WY
Friday (July 25) 
  • Morning: AN AON BAH CHTR CNC FHB FLG GNTX HCA LEA LKFN OMF POR PSX SAIA STEL SXT TNET WNC
  • Afternoon: HTH

Friday, July 18, 2025

===Telomir Pharmaceuticals (TELO) : Telomir-1 reverses epigenetic gene silencing of STAT1

 

Telomir Pharmaceuticals demonstrates Telomir-1 reverses epigenetic gene silencing of STAT1, restoring tumor suppressor in human prostate cancer cells, outperforming chemotherapy and Rapamycin
  • The co reported new preclinical results evaluating the effects of its lead candidate, Telomir-1, in a murine xenograft model using PC3 human prostate cancer cells. The data demonstrated that Telomir-1 reversed epigenetic silencing by DNA methylation of the STAT1 gene, a tumor suppressor and immune response regulator, in a dose-dependent manner. STAT1 is frequently silenced in advanced cancers via promoter hypermethylation, disrupting immune detection and apoptotic pathways.
  • In this study, Telomir-1 administered orally daily for 21 days resulted in full reversal of STAT1 hypermethylation in tumor tissue. No such reversal was observed in the Paclitaxel (PTX) group, and only partial demethylation was observed with Rapamycin In addition to STAT1, Telomir-1 also reduced hypermethylation of TMS1 (also known as ASC or PYCARD), a pro-apoptotic tumor suppressor commonly silenced in prostate cancer. While PTX and Rapamycin showed comparable or greater effects on TMS1 methylation, Telomir-1 is unique in its ability to modulate both STAT1 and TMS1-two genes that together regulate immune response and apoptosis. Importantly, TMS1 also plays a central role in inflammasome activation, which not only contributes to tumor cell death but also supports the immune system's ability to detect and clear abnormal cells. When TMS1 is hypermethylated, this immune signaling pathway is disrupted-reducing caspase-1 activation and inflammatory cytokine release. This can impair immune surveillance and allow cancer cells to persist undetected. By reducing TMS1 hypermethylation, Telomir-1 may help restore immune recognition and enhance the tumor's sensitivity to both chemotherapy and immunotherapy.

==Regions Financial (RF) reported earnings on Fri 18 July 25 (b/o)

 

BIRMINGHAM, Ala. (AP) — BIRMINGHAM, Ala. (AP) — Regions Financial Corp. (RF) on Friday reported second-quarter earnings of $563 million.

The Birmingham, Alabama-based bank said it had earnings of 59 cents per share. Earnings, adjusted for non-recurring costs, came to 60 cents per share.

The results topped Wall Street expectations. The average estimate of 11 analysts surveyed by Zacks Investment Research was for earnings of 56 cents per share.

The holding company for Regions Bank posted revenue of $2.43 billion in the period. Its revenue net of interest expense was $1.91 billion, which also topped Street forecasts. Six analysts surveyed by Zacks expected $1.85 billion.